• SIOP ASIA 2020

Prof. Nirali N. Shah

Dr. Nirali Shah serves as the clinical head of the pediatric hematologic malignancies section of the Pediatric Oncology Branch. Her primary research interests focus on translation of immunotherapeutic approaches to treat high-risk hematologic malignancies in children, adolescents and young adults. She has a particular interest in prevention and treatment of relapsed disease after allogeneic hematopoietic stem cell transplantation. Her clinical trials focus on exploring and optimizing chimeric antigen receptor (CAR) T-cell based strategies and other antibody based therapies to target surface proteins found on leukemia cells to improve outcomes for chemotherapy refractory disease. Additional areas of expertise include pediatric hematopoietic stem cell transplantation in both malignant and non-malignant diseases, development of early phase clinical trials in pediatric oncology, and ethical considerations for inclusion of minors in research. Dr. Shah also serves as the NCI Fellowship Program director for the joint Johns Hopkins Hospital-National Cancer Institute Pediatric Hematology-Oncology Fellowship Program.

Areas of Expertise

  • Chimeric Antigen Receptor (CAR)-T cell therapy for pediatric leukemia
  • Immunotherapy for relapsed/refractory pediatric leukemia and lymphoma
  • Early phase clinical trials in pediatric oncology
  • Hematopoietic stem cell transplantation
  • Bioethics